Author: Jose Almirall
Abstract:
Ion mobility spectrometry (IMS) has been described
throughout the scientific literature as both a stand-alone separation technique
and as a hyphenated technique used to enhance other analytical determinations.
Despite this flexibility and versatility, the applications
of IMS have not grown quickly as that of gas chromatography (GC) or liquid
chromatography (LC).
This research describes the use of IMS as a lab-based
analytical technique able to perform separations on par with GC and LC
separations. It was motivated by the necessity to perform rapid and inexpensive
analyses on substances commonly encountered by law enforcement, in particular,
analysis of controlled amphetamine type substances and the emerging designer
drugs, some of which are very similar in structure.
Experiments were carried out utilizing ion mobility
spectrometry and other analytical techniques throughout this research project.
The results from this research suggest that chiral
separation by an achiral modifier in the gas phase and the detection and
identification of designer drugs are possible using an electrospray ionization
ion mobility mass spectrometer (ESI-IMS-MS) with an optimal solvent system. A
total of four peer-reviewed manuscripts were published and more than 20 oral
and poster presentations were presented at national and international
scientific conferences.
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