Author: Ryan Lilien
Abstract:
TopMatch technology shows excellent and continually
improving match accuracy; however, in order to fully establish the base
credibility of the platform, it was necessary to establish best-scamming
practices and to demonstrate that the method meets the quality-control criteria
of other forensic instruments.
The current project aimed to enhance TopMatch by
establishing best practices and conducting a set of methodology studies. The
project followed the intent of the Scientific Working Group on DNA Analysis
Methods’ Validation Guidelines for Analysis Methods document. That document
describes seven validation criteria for new scientific methods: Accuracy,
Stability, Precision, Repeatability, Reproducibility, Contamination Risk, and
Performance Checks.
The current project complements the previous studies on
"Accuracy" and evidence "Stability" by addressing the
remaining issues of Precision, Repeatability, Reproducibility, Contamination
Risk, and Performance Checks. In addition, researchers will study the effects
of Cleaning Protocols, Focus Variation, and Ambient Lighting Variation.
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